首页> 外文OA文献 >M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors

【2h】

M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors

机译：m13噬菌体功能化单壁碳纳米管作为纳米探针用于靶向肿瘤的第二次近红外窗口荧光成像

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Second near-infrared (NIR) window light (950–1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered multifunctional M13 phage can assemble fluorescent single-walled carbon nanotubes (SWNTs) and ligands for targeted fluorescence imaging of tumors. M13-SWNT probe is detectable in deep tissues even at a low dosage of 2 μg/mL and up to 2.5 cm in tissue-like phantoms. Moreover, targeted probes show specific and up to 4-fold improved uptake in prostate specific membrane antigen positive prostate tumors compared to control nontargeted probes. This M13 phage-based second NIR window fluorescence imaging probe has great potential for specific detection and therapy monitoring of hard-to-detect areas.

机译：第二种近红外（NIR）窗口光（950–1400 nm）由于其在组织中的深穿透深度和低的组织自发荧光，因此对于体内荧光成像很有吸引力。在这里，我们显示了基因工程多功能M13噬菌体可以组装荧光单壁碳纳米管（SWNTs）和配体，用于肿瘤的靶向荧光成像。 M13-SWNT探针即使在低剂量的2μg/ mL的情况下也可在深部组织中检测到，而在类似组织的体模中的最大剂量为2.5 cm。而且，与对照非靶向探针相比，靶向探针在前列腺特异性膜抗原阳性的前列腺肿瘤中显示出特异性的和高达4倍的改善的摄取。这种基于M13噬菌体的第二NIR窗口荧光成像探针具有很大的潜力，可用于难以检测区域的特异性检测和治疗监测。

著录项

作者
Yi, Hyunjung; Ghosh, Debadyuti; Ham, Moon-Ho; Qi, Jifa; Barone, Paul W.; Strano, Michael S.; Belcher, Angela M.;
展开▼
作者单位

展开▼
年度 2011
总页数
原文格式 PDF
正文语种 en_US
中图分类

相似文献

外文文献
中文文献
专利

1. M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors [J] . Yi H., Ghosh D., Ham M.-H., Nano letters . 2012,第3期

机译：M13噬菌体功能化的单壁碳纳米管作为纳米探针，用于靶向肿瘤的第二次近红外窗口荧光成像
2. In Vivo Fluorescence Imaging in the Second Near-Infrared Window with Long Circulating Carbon Nanotubes Capable of Ultrahigh Tumor Uptake [J] . Joshua T. Robinson, Guosong Hong, Yongye Liang, Journal of the American Chemical Society . 2012,第25期

机译：具有超高肿瘤吸收能力的长循环碳纳米管在第二个近红外窗口中的体内荧光成像
3. pH-Activatable tumor-targeting gold nanoprobe for near-infrared fluorescence/CT dual-modal imaging in vivo [J] . Tang Yao, Shi Hongyuan, Cheng Di, Colloids and Surfaces, B. Biointerfaces . 2019,第期

机译：pH-可活化的肿瘤靶向金纳孔，用于近红外荧光/ CT双式成像在体内
4. Microscopy, Fluorescence, and Confocal Raman Imaging of Biotinylated Single-Walled Carbon Nanotubes Bound to Breast Tumor Cells [C] . I.H. Musselman, P. Bajaj, C. Mikoryak, Microscopy and microanalysis.;Microscopy and microanalysis. . -1

机译：绑定到乳腺肿瘤细胞的生物素化单壁碳纳米管的显微镜，荧光和共聚焦拉曼成像
5. Fabrication of a hyperspectral microscope to detect near-infrared photoluminescence from single-walled carbon nanotubes [D] . Wallack, Matthew N. 2008

机译：制造高光谱显微镜以检测单壁碳纳米管的近红外光致发光
6. M13 phage-functionalized single-walled carbon nanotubes as nanoprobes for second near-infrared window fluorescence imaging of targeted tumors [O] . HYUNJUNG YI, DEBADYUTI GHOSH, MOON-HO HAM, -1

机译：M13噬菌体官能化的单壁碳纳米管作为纳米体抑制靶肿瘤的第二近红外窗口荧光成像
7. Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes [O] . Ghosh Debadyuti, Bagley Alexander F., Na Young Jeong, 2014

机译：使用靶向m13稳定的单壁碳纳米管对亚毫米肿瘤进行深入，无创的成像和手术指导

M13 Phage-Functionalized Single-Walled Carbon Nanotubes As Nanoprobes for Second Near-Infrared Window Fluorescence Imaging of Targeted Tumors

摘要

著录项

相似文献

相关主题

期刊订阅